• A new study found that cinnamaldehyde, a primary active ingredient in cinnamon, can activate receptors that affect drug metabolism, potentially leading to herb-drug interactions.
• Researchers advise caution with cinnamon supplements, especially for individuals with chronic conditions like hypertension, diabetes, cancer, or those taking blood thinners, liver medications or other supplements like turmeric.
• While culinary use of cinnamon is unlikely to cause problems, overconsumption of concentrated cinnamon products requires further investigation and consultation with healthcare providers.

A recent study published in Food Chemistry: Molecular Sciences has raised concerns about the potential for cinnamon, particularly in concentrated forms like supplements, to interfere with the metabolism of certain prescription medications. The study investigated cinnamaldehyde, a key component of cinnamon, and its impact on drug metabolism. While limited culinary use is generally considered safe, the researchers recommend caution regarding the overconsumption of cinnamon supplements, particularly for individuals with pre-existing health conditions or those taking specific medications. Further clinical research is needed to fully understand the extent of these potential interactions.

• What: A study reveals that cinnamaldehyde, found in cinnamon, can affect drug metabolism, potentially interfering with the effectiveness of certain prescription medications.
• Who: Researchers at unnamed institutions, Dr. Leana Wen (CNN wellness expert), Bill Gurley (University of Mississippi's National Center for Natural Products Research), individuals with chronic conditions (hypertension, diabetes, cancer, etc.), and those taking blood thinners or liver medications.
• When: The study was recently published in Food Chemistry: Molecular Sciences. The Washington Post article was published in May 2025.
• Where: The research was conducted in a laboratory setting, simulating human digestion. The implications are global, affecting anyone consuming cinnamon supplements.

The study's findings suggest a potential risk associated with the overconsumption of cinnamon, particularly in concentrated supplement form. The activation of xenobiotic receptors by cinnamon components could lead to the rapid clearing of prescription drugs from the body, reducing their effectiveness. The lack of FDA regulation for dietary supplements emphasizes the importance of consumer awareness and consultation with healthcare providers before starting any supplement regimen. Further research is needed to quantify the specific interactions between cinnamon and various medications and to establish safe consumption levels.

We know there’s a potential for cinnamaldehyde to activate these receptors that can pose a risk for drug interactions. That’s what could happen, but we won’t know exactly what will happen until we do a clinical study.

While moderate culinary use of cinnamon is generally considered safe, the study highlights a potential risk associated with the overconsumption of cinnamon supplements. The findings underscore the need for further research to fully understand the extent of potential drug interactions and to establish safe consumption guidelines. Individuals considering cinnamon supplements, especially those with pre-existing health conditions or taking prescription medications, should consult with their healthcare providers to assess potential risks and benefits.